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AI-based multi-PRS models outperform classical single-PRS models

27 Jun 2023

Abstract excerpt

Polygenic risk scores (PRS) calculate the risk for a specific disease based on the weighted sum of associated alleles from different genetic loci in the germline estimated by regression models. Recent advances in genetics made it possible to create polygenic predictors of complex human traits, including risks for many important complex diseases, such as cancer, diabetes, or cardiovascular diseases, typically...

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PMID: 37441549
DOI: 10.3389/fgene.2023.1217860

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