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Article

Persistent postremission clonal hematopoiesis shapes the relapse trajectories of acute myeloid leukemia.

Blood advances - 22 Apr 2025

Chow Ryan D, Velu Priya, Deihimi Safoora, Belman Jonathan, Youn Angela, Shah Nisargbhai, Luger Selina M, Carroll Martin P, Morrissette Jennifer, Bowman Robert L

Abstract excerpt

ABSTRACT: Mutations found in acute myeloid leukemia (AML) such as DNMT3A, TET2, and ASXL1 can be found in the peripheral blood of healthy adults, a phenomenon termed clonal hematopoiesis (CH). These mutations are thought to represent the earliest genetic events in the evolution of AML. Genomic studies on samples acquired at diagnosis, remission, and at relapse have demonstrated significant stability of CH...

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Topics

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Share to Clonal Hematopoiesis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3A

Share to fms-Like Tyrosine Kinase 3

Share to Leukemia, Myeloid, Acute

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Source

Open in PubMed Open full text

Identifiers

PMID: 39938015
DOI: 10.1182/bloodadvances.2024015149
PMCID: PMC12008691

Genes

FLT3
NPM1
ASXL1
DNMT3A
TET2
CBL
SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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