Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clonal evolution of pre-leukemic hematopoietic stem cells precedes human acute myeloid leukemia.

Best practice & research. Clinical haematology - 1 Jan 2000

Majeti Ravindra

Abstract excerpt

Massively parallel DNA sequencing has uncovered recurrent mutations in many human cancers. In acute myeloid leukemia (AML), cancer genome/exome resequencing has identified numerous recurrently mutated genes with an average of 5 mutations in each case of de novo AML. In order for these multiple mutations to accumulate in a single lineage of cells, they are serially acquired in clones of self-renewing hematopoietic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Chromosomal Proteins, Non-Histone
Share to Cohesins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to DNA, Neoplasm

Share to Hematopoietic Stem Cells

Share to Leukemia, Myeloid, Acute

Share to Neoplastic Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 25455271
DOI: 10.1016/j.beha.2014.10.003
PMCID: PMC5419218

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal evolution of pre-leukemic hematopoietic stem cells precedes human acute myeloid leukemia.PMID 25455271Read ↗

Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis.Semantic proximity Read ↗

Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.Semantic proximity Read ↗

Concise Review: Preleukemic Stem Cells: Molecular Biology and Clinical Implications of the Precursors to Leukemia Stem CellsSemantic proximity Read ↗

Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer?Semantic proximity Read ↗

The Crossroads of Clonal Evolution, Differentiation Hierarchy, and Ontogeny in Leukemia DevelopmentSemantic proximity Read ↗

[Leukemia stem cell and clonal evolution].Semantic proximity Read ↗

Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets.Semantic proximity Read ↗

[Clonal evolution of myeloid malignancies].Semantic proximity Read ↗

Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid LeukemiaSemantic proximity Read ↗

Clonal Architecture and Evolutionary Dynamics in Acute Myeloid LeukemiasSemantic proximity Read ↗

Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia initiation and relapse.Semantic proximity Read ↗

Early drivers of clonal hematopoiesis shape the evolutionary trajectories of <i>de novo</i> acute myeloid leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.