Article
Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia.
Nature communications - 18 Aug 2016
Hirsch Pierre, Zhang Yanyan, Tang Ruoping, Joulin Virginie, Boutroux Hélène, Pronier Elodie, Moatti Hannah, Flandrin Pascale, Marzac Christophe, Bories Dominique, Fava Fanny, Mokrani Hayat, Betems Aline, Lorre Florence, Favier Rémi, Féger Frédéric, Mohty Mohamad, Douay Luc, Legrand Ollivier, Bilhou-Nabera Chrystèle, Louache Fawzia, Delhommeau François
Abstract excerpt
In acute myeloid leukaemia (AML) initiating pre-leukaemic lesions can be identified through three major hallmarks: their early occurrence in the clone, their persistence at relapse and their ability to initiate multilineage haematopoietic repopulation and leukaemia in vivo. Here we analyse the clonal composition of a series of AML through these characteristics. We find that not only DNMT3A mutations, but also...
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