Article
Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.
Science translational medicine - 29 Aug 2012
Jan Max, Snyder Thomas M, Corces-Zimmerman M Ryan, Vyas Paresh, Weissman Irving L, Quake Stephen R, Majeti Ravindra
Abstract excerpt
Given that most bone marrow cells are short-lived, the accumulation of multiple leukemogenic mutations in a single clonal lineage has been difficult to explain. We propose that serial acquisition of mutations occurs in self-renewing hematopoietic stem cells (HSCs). We investigated this model through genomic analysis of HSCs from six patients with de novo acute myeloid leukemia (AML). Using exome sequencing, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.