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Article

Clonal hierarchy of main molecular lesions in acute myeloid leukaemia.

British journal of haematology - 1 Aug 2020

Herudkova Zdenka, Culen Martin, Folta Adam, Jeziskova Ivana, Cerna Jana, Loja Tomas, Tom Nikola, Smejkal Jiri, Semerad Lukas, Dvorakova Dana, Mayer Jiri, Racil Zdenek

Abstract excerpt

Genetic mutations in acute myeloid leukaemia (AML) are assumed to occur in a sequential order; however, the predominant hierarchical roles of specific mutated genes have not been fully described. In this study, we aimed to determine the clonal involvement of the most frequent AML-associated mutations. Using a targeted sequencing panel for 18 genes, we traced changes and relative clonal contribution of mutations...

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PMID: 31822038
DOI: 10.1111/bjh.16341

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