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Article

Molecular characterization of a second myeloid neoplasm developing after treatment for acute myeloid leukemia.

Leukemia - 1 Mar 2020

Hartmann Luise, Nadarajah Niroshan, Meggendorfer Manja, Höllein Alexander, Vetro Calogero, Kern Wolfgang, Haferlach Torsten, Haferlach Claudia, Stengel Anna

Abstract excerpt

Therapy-related myeloid neoplasms (tMN) following successful treatment of acute myeloid leukemia (AML) are rare and poorly characterized. To evaluate the presence of a common ancestral clone, we performed whole-exome sequencing of 25 patients at AML diagnosis, tMN diagnosis (tMDS: 13; tAML: 12), and matched remission samples, identifying 607 mutations affecting 504 different genes (46 recurrently mutated). Number...

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Identifiers

PMID: 31719678
DOI: 10.1038/s41375-019-0633-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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