Article

Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers

2024-12-12

Abstract excerpt

<title>Abstract</title> <p>First-line immune checkpoint inhibitor (ICI) combinations show responses in subsets of hepatocellular carcinoma (HCC) patients. Nearly half of HCCs are Wnt-active with mutations in <italic>CTNNB1</italic> (encoding for β-catenin), <italic>AXIN1/2</italic>, or <italic>APC</italic>, and demonstrate limited benefit to ICI due to an immune excluded tumor microenvironment. We show significan...

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Literature Corpus work: 67167a0b-acb8-549e-9d5f-a4721c3d6dec
DOI: 10.21203/rs.3.rs-5494074/v1

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