Article
Emerging role of oncogenic ß-catenin in exosome biogenesis as a driver of immune escape in hepatocellular carcinoma.
eLife - 15 Jul 2024
Dantzer Camille, Vaché Justine, Brunel Aude, Mahouche Isabelle, Raymond Anne-Aurélie, Dupuy Jean-William, Petrel Melina, Bioulac-Sage Paulette, Perrais David, Dugot-Senant Nathalie, Verdier Mireille, Bessette Barbara, Billottet Clotilde, Moreau Violaine
Abstract excerpt
Immune checkpoint inhibitors have produced encouraging results in cancer patients. However, the majority of ß-catenin-mutated tumors have been described as lacking immune infiltrates and resistant to immunotherapy. The mechanisms by which oncogenic ß-catenin affects immune surveillance remain unclear. Herein, we highlighted the involvement of ß-catenin in the regulation of the exosomal pathway and, by extension,...
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