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Article

The biology of Hepatocellular carcinoma: implications for genomic and immune therapies.

Molecular cancer - 30 Aug 2017

Khemlina Galina, Ikeda Sadakatsu, Kurzrock Razelle

Abstract excerpt

Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is a leading cause of cancer-related death worldwide. It is highly refractory to most systemic therapies. Recently, significant progress has been made in uncovering genomic alterations in HCC, including potentially targetable aberrations. The most common molecular anomalies in this malignancy are mutations in the TERT promoter, TP53,...

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Topics

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Share to Biomarkers, Tumor
Share to Carcinoma, Hepatocellular
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genomics

Share to Immunotherapy

Share to Liver Neoplasms

Share to Signal Transduction

Source

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Identifiers

PMID: 28854942
DOI: 10.1186/s12943-017-0712-x
PMCID: PMC5577674

Genes

CTNNB1
TP53
AXIN1
PTEN
ARID1A
CCND1
CDKN2A
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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