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Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers

29 May 2025

Abstract excerpt

First-line immune checkpoint inhibitor (ICI) combinations show responses in subsets of hepatocellular carcinoma (HCC) patients. Nearly half of HCCs are Wnt-active with mutations in CTNNB1 (encoding for β-catenin), AXIN1/2, or APC, and demonstrate heterogeneous and limited benefit to ICI due to an immune excluded tumor microenvironment. We show significant tumor responses in multiple β-catenin-mutated...

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PMID: 40442146
DOI: 10.1038/s41467-025-60457-2

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