Article

Liver fibrosis uncouples tumor control from survival after multikinase inhibitor immunotherapy in hepatocellular carcinoma

2023-10-23

Abstract excerpt

Combining multikinase inhibitors with immune checkpoint blockade improves tumor control in hepatocellular carcinoma (HCC), but survival benefits remain inconsistent. To define this discordance, we integrated COSMIC-312 with orthotopic and autochthonous murine HCC models with or without liver fibrosis. In patients treated with cabozantinib plus atezolizumab, baseline liver function stratified overall survival but n...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5231525f-cade-5a34-8d4d-758e95631244
DOI: 10.1101/2023.10.20.563378

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Liver fibrosis uncouples tumor control from survival after multikinase inhibitor immunotherapy in hepatocellular carcinomaDOI 10.1101/2023.10.20.563378Read

An integrated single-cell atlas of checkpoint inhibitor-induced liver injury links shared liver-tumour CD8+ T cell clones to cytotoxicity and macrophage crosstalksSemantic proximity Read

The Oncology of Liver Cancer: Integrating Molecular Insights with Therapeutic InnovationSemantic proximity Read

Reversing immunosuppression in the tumor microenvironment of fibrolamellar carcinoma via PD-1 and IL-10 blockadeSemantic proximity Read

Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancersSemantic proximity Read

Hepatocellular Carcinoma Immune Landscape and the Potential of Immunotherapies.Semantic proximity Read

Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancersSemantic proximity Read

Tumor biology and immune infiltration define primary liver cancer subsets linked to overall survival after immunotherapySemantic proximity Read

Single-cell and spatial atlas of steatotic liver disease-related hepatocellular carcinomaSemantic proximity Read

Caspase-1 regulates TBK1 and PPARα to suppress steatosis-associated hepatocarcinogenesisSemantic proximity Read

Spatial Analysis Uncovers Immune Resistance Mechanisms in Non-Beneficial Hepatocellular Carcinoma Treated with Y90 Radioembolization-NivolumabSemantic proximity Read

WITHDRAWN: Natural Killer Cell-Mediated Immunosurveillance Drives Liver Cancer Evolution Through Cancer Stemness Enhancement and Lipid Metabolism ReprogrammingSemantic proximity Read