Article

IS-PRM-based peptide targeting informed by long-read sequencing for alternative proteome detection

2024-04-01

Abstract excerpt

<h4>ABSTRACT</h4> Alternative splicing is a major contributor of transcriptomic complexity, but the extent to which transcript isoforms are translated into stable, functional protein isoforms is unclear. Furthermore, detection of relatively scarce isoform-specific peptides is challenging, with many protein isoforms remaining uncharted due to technical limitations. Recently, a family of advanced targeted MS strate...

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Literature Corpus work: 66f88c1a-ebae-566a-bd74-c422a76befa6
DOI: 10.1101/2024.04.01.587549

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