Article

Single-molecule, full-length transcript isoform sequencing reveals disease mutation-associated RNA isoforms in cardiomyocytes

2021-06-18

Abstract excerpt

Alternative splicing generates differing RNA isoforms that govern phenotypic complexity of eukaryotes. Its malfunction underlies many diseases, including cancer and cardiovascular diseases. Comparative analysis of RNA isoforms at the genome-wide scale has been difficult. Here, we established an experimental and computational pipeline that performs de novo transcript annotation and accurately quantifies transcript...

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Literature Corpus work: 4695bbb0-8be5-5fc7-bdf6-906280fcaef0
DOI: 10.1101/2021.06.18.448952

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