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Article

Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes.

Nature communications - 9 Jul 2021

Zhu Chenchen, Wu Jingyan, Sun Han, Briganti Francesca, Meder Benjamin, Wei Wu, Steinmetz Lars M

Abstract excerpt

Alternative splicing generates differing RNA isoforms that govern phenotypic complexity of eukaryotes. Its malfunction underlies many diseases, including cancer and cardiovascular diseases. Comparative analysis of RNA isoforms at the genome-wide scale has been difficult. Here, we establish an experimental and computational pipeline that performs de novo transcript annotation and accurately quantifies transcript...

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Identifiers

PMID: 34244519
DOI: 10.1038/s41467-021-24484-z
PMCID: PMC8270901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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