Article

Sample-specific haplotype-resolved protein isoform characterization via long-read RNA-seq-based proteogenomics

2025-11-24

Abstract excerpt

Protein isoform inference from bottom-up mass spectrometry (MS) relies on database search strategies that assume the reference protein database accurately reflects the full repertoire of genetic and transcriptomic states present in the sample being analyzed. Long-read RNA sequencing (lrRNA-seq) now enables simultaneous recovery of complete transcript (splice) structures and the genetic variants present on each mol...

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Literature Corpus work: 41d687e9-0559-5175-b431-900d576d83ec
DOI: 10.1101/2025.11.21.689818

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