Article

End-to-end proteogenomics for discovery of cryptic and non-canonical cancer proteoforms using long-read transcriptomics and multi-dimensional proteomics

2025-08-28

Abstract excerpt

<h4>ABSTRACT</h4> Modern mass spectrometry now permits genome-scale quantitative measurements of biological proteomes. However, current approaches remain hindered by incomplete representation of biological variability of protein sequences in canonical reference proteomes, limiting studies to already annotated proteoforms. This, combined with reliance on tryptic peptides and limited sample complexity reduction tec...

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Identifiers and source

Literature Corpus work: ecbd6288-c153-5368-b520-73ba3a3e0aba
DOI: 10.1101/2025.08.23.671943

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