Article

LRP2: A proteogenomics pipeline for long-read informed protein isoform analysis and discovery

2026-05-31

Abstract excerpt

<h4>Summary</h4> Most human genes produce multiple RNA isoforms, yet it remains unclear which isoforms are translated into stable, functional proteins. Long-read RNA-sequencing resolves full-length transcript structures and, when paired with mass spectrometry, can provide empirical evidence of isoform translation. Despite this opportunity, comprehensive workflows integrating isoform discovery, open reading frame...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cfebb050-19e8-5117-8703-420d15aee4f0
DOI: 10.64898/2026.05.27.728216

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LRP2: A proteogenomics pipeline for long-read informed protein isoform analysis and discoveryDOI 10.64898/2026.05.27.728216Read

Biosurfer for systematic tracking of regulatory mechanisms leading to protein isoform diversitySemantic proximity Read

SCOTCH: isoform-level characterization of gene expression through long-read single-cell RNA sequencingSemantic proximity Read

VIsoQLR: an interactive tool for the detection, quantification and fine-tuning of isoforms using long-read sequencingSemantic proximity Read

cloudrnaSPAdes: Isoform assembly using bulk barcoded RNA sequencing dataSemantic proximity Read

IFDlong: an isoform and fusion detector for accurate annotation and quantification of long-read RNA-seq dataSemantic proximity Read

A systematic benchmark of Nanopore long read RNA sequencing for transcript level analysis in human cell linesSemantic proximity Read

PPLine: An Automated Pipeline for SNP, SAP, and Splice Variant Detection in the Context of Proteogenomics.Semantic proximity Read

CLASS: Accurate and Efficient Splice Variant Annotation from RNA-seq ReadsSemantic proximity Read

Comprehensive characterization of single cell full-length isoforms in human and mouse with long-read sequencingSemantic proximity Read

Accurate strand-specific long-read transcript isoform discovery and quantification at bulk, single-cell, and single-nucleus resolutionSemantic proximity Read

ORF Capture-Seq: a versatile method for targeted identification of full-length isoformsSemantic proximity Read

Systematic assessment of long-read RNA-seq methods for transcript identification and quantificationSemantic proximity Read