Splice junction centric approach to identify translated noncanonical isoforms in the human proteome

Abstract excerpt

RNA sequencing has led to the discovery of many transcript isoforms created by alternative splicing, but the translational status and functional significance of most alternative splicing events remain unknown. Here we applied a splice junction-centric approach to survey the landscape of protein alternative isoform expression in the human proteome. We focused on alternative splice events where pairs of splice junct...

Topics

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• Alternative Splicing
• Cardiomyopathy, Dilated
• Feasibility Studies
• Gene Editing
• Mutation
• Renal Insufficiency, Chronic
• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factor Receptor-1

Identifiers and source

Literature Corpus work

eb79d1bb-fabf-5e51-b05d-d072b627cc32

DOI

10.1101/372995