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Article

RNA and disease.

Cell - 20 Feb 2009

Cooper Thomas A, Wan Lili, Dreyfuss Gideon

Abstract excerpt

Cellular functions depend on numerous protein-coding and noncoding RNAs and the RNA-binding proteins associated with them, which form ribonucleoprotein complexes (RNPs). Mutations that disrupt either the RNA or protein components of RNPs or the factors required for their assembly can be deleterious. Alternative splicing provides cells with an exquisite capacity to fine-tune their transcriptome and proteome in...

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Identifiers

PMID: 19239895
DOI: 10.1016/j.cell.2009.02.011
PMCID: PMC2866189

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