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Article

A nuclear RNA degradation code is recognized by PAXT for eukaryotic transcriptome surveillance.

Molecular cell - 17 Apr 2025

Soles Lindsey V, Liu Liang, Zou Xudong, Yoon Yoseop, Li Shuangyu, Tian Lusong, Valdez Marielle, Yu Angela M, Yin Hong, Li Wei, Ding Fangyuan, Seelig Georg, Li Lei, Shi Yongsheng

Abstract excerpt

The RNA exosome plays critical roles in eukaryotic RNA degradation, but how it specifically recognizes its targets remains unclear. The poly(A) tail exosome targeting (PAXT) connection is a nuclear adaptor that recruits the exosome to polyadenylated RNAs, especially transcripts polyadenylated at intronic poly(A) sites. Here, we show that PAXT-mediated RNA degradation is induced by the combination of a 5' splice...

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Share to 3' Untranslated Regions
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40187348
DOI: 10.1016/j.molcel.2025.03.010
PMCID: PMC12010247

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NRDC

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