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A computational method for direct imputation of cell type-specific expression profiles and cellular compositions from bulk-tissue RNA-Seq in brain disorders

2020-05-31

Abstract excerpt

The importance of cell type-specific gene expression in disease-relevant tissues is increasingly recognized in genetic studies of complex diseases. However, the vast majority of gene expression studies are conducted on bulk tissues, necessitating computational approaches to infer biological insights on cell type-specific contribution to diseases. Several computational methods are available for cell type deconvolut...

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Literature Corpus work
c46504e5-5956-5787-8005-57d10fafd27d
DOI
10.1101/2020.05.28.121483
Open publication

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A computational method for direct imputation of cell type-specific expression profiles and cellular compositions from bulk-tissue RNA-Seq in brain disordersDOI 10.1101/2020.05.28.121483
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