Polygenic enrichment analysis in multi-omics levels identifies cell/tissue specific associations with schizophrenia based on single-cell RNA sequencing data.

doi:10.1016/j.schres.2025.02.008

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Article

Polygenic enrichment analysis in multi-omics levels identifies cell/tissue specific associations with schizophrenia based on single-cell RNA sequencing data.

Schizophrenia research - 1 Mar 2025

Cheng Bolun, Wen Yan, Wei Wenming, Cheng Shiqiang, Pan Chuyu, Meng Peilin, Liu Li, Yang Xuena, Liu Huan, Jia Yumeng, Zhang Feng

Abstract excerpt

OBJECTIVE: Understanding the specific cellular origin and tissue heterogeneity in schizophrenia is critically important for exploring the disease etiology. This study aims to investigate these aspects by performing multiple analyses based on omics data. METHOD: We performed single-cell disease relevance score (scDRS) algorithm to link brain single-cell RNA sequencing (scRNA-seq) with schizophrenia risk across...

Read the complete abstract on PubMed

Topics

Schizophrenia
Humans
Single-Cell Analysis
Sequence Analysis, RNA
Multifactorial Inheritance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Brain

Genome-Wide Association Study

Microglia

Male

Genetic Predisposition to Disease

Female

Neurons

Multiomics

Source

Open in PubMed

Identifiers

PMID: 40036903
DOI: 10.1016/j.schres.2025.02.008

Genes

FN1
SCUBE3

Provenance

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