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Article

Integrating cell-type-specific gene expression and genome-wide associations identifies risk genes for schizophrenia.

Molecular psychiatry - 1 Oct 2026

Lou Wenqi, Dang Xinglun, Luo Xiong-Jian

Abstract excerpt

Integrative studies such as transcriptome-wide association studies (TWAS) and Mendelian randomization (MR) have identified multiple risk genes whose expression level is associated with schizophrenia (SCZ). However, the vast majority of integrative studies are based on quantitative trait loci (QTL) data from bulk brain tissues. Given that gene expression and genetic regulatory effects are highly dependent on cell...

Read the complete abstract on PubMed

Topics

Schizophrenia
Humans
Genome-Wide Association Study
Quantitative Trait Loci
Genetic Predisposition to Disease
Brain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Gene Expression

Mendelian Randomization Analysis

Transcriptome

Neurons

Source

Identifiers

PMID: 42106519
DOI: 10.1038/s41380-026-03652-x

Genes

MAU2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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