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Article

The I Ks Ion Channel Activator Mefenamic Acid Requires KCNE1 and Modulates Channel Gating in a Subunit-Dependent Manner.

Molecular pharmacology - 1 Feb 2020

Wang Yundi, Eldstrom Jodene, Fedida David

Abstract excerpt

The pairing of KCNQ1 and KCNE1 subunits together mediates the cardiac slow delayed rectifier current (I Ks ), which is partly responsible for cardiomyocyte repolarization and physiologic shortening of the cardiac action potential. Mefenamic acid, a nonsteroidal anti-inflammatory drug, has been identified as an I Ks activator. Here, we provide a biophysical and pharmacological characterization of mefenamic acid's...

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Identifiers

PMID: 31722973
DOI: 10.1124/mol.119.117952

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