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Article

Characterization of an LQT5-related mutation in KCNE1, Y81C: implications for a role of KCNE1 cytoplasmic domain in IKs channel function.

Heart rhythm - 1 Sept 2006

Wu Dong-Mei, Lai Ling-Ping, Zhang Mei, Wang Hui-Liang, Jiang Min, Liu Xian-Sheng, Tseng Gea-Ny

Abstract excerpt

BACKGROUND: Y81C is a new long QT-5 (LQT5)-related KCNE1 mutation, which is located in the post-transmembrane domain (post-TMD) region in close proximity to three other LQT5 mutations (S74L, D76N, and W87R). OBJECTIVE: We examine the effects of Y81C on the function and drug sensitivity of the slow delayed rectifier channel (I(Ks)) formed by KCNE1 with pore-forming KCNQ1 subunits. We also infer a structural basis...

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Identifiers

PMID: 16945797
DOI: 10.1016/j.hrthm.2006.05.022

Genes

KCNQ1

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