Article

Structural basis of slow gating and arrhythmogenic modulation in the IKs channel complex

2025-08-13

Abstract excerpt

<title>Abstract</title> <p>The slowly activating delayed-rectifier K⁺ (I<sub>Ks</sub>) current, generated by the voltage-gated K⁺ channel KCNQ1 and its auxiliary subunit KCNE1, is essential for ventricular repolarization and cardiac rhythm. Mutations in either subunit underlie congenital arrhythmias such as long QT syndrome (LQTS) and atrial fibrillation (AF). However, the structural mechanisms underlying the hal...

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Literature Corpus work: d5a1f67c-e229-5625-bb59-af4fb00807a8
DOI: 10.21203/rs.3.rs-6949329/v1

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