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Article

Structural basis of slow activation gating in the cardiac I Ks channel complex.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2011

Strutz-Seebohm Nathalie, Pusch Michael, Wolf Steffen, Stoll Raphael, Tapken Daniel, Gerwert Klaus, Attali Bernard, Seebohm Guiscard

Abstract excerpt

Accessory β-subunits of the KCNE gene family modulate the function of various cation channel α-subunits by the formation of heteromultimers. Among the most dramatic changes of biophysical properties of a voltage-gated channel by KCNEs are the effects of KCNE1 on KCNQ1 channels. KCNQ1 and KCNE1 ar...

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Source

Identifiers

PMID: 21691061
DOI: 10.1159/000329965

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21691061-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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Structural basis of slow activation gating in the cardiac I Ks channel complex.PMID 21691061Read ↗

Structural basis of slow gating and arrhythmogenic modulation in the IKs channel complexSemantic proximity Read ↗

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KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate.Semantic proximity Read ↗

KCNE1 remodels the voltage sensor of Kv7.1 to modulate channel function.Semantic proximity Read ↗

A generic binding pocket for small molecule <i> I <sub>Ks</sub> </i> activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexesSemantic proximity Read ↗

The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure.Semantic proximity Read ↗

Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gatingSemantic proximity Read ↗

Insights into Cardiac IKs (KCNQ1/KCNE1) Channels RegulationSemantic proximity Read ↗

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Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channels.Semantic proximity Read ↗

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