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Loss of riboflavin biosynthesis leads to accumulation of select aromatic amino acids and loss of infectivity in <i>Mycobacterium tuberculosis</i>

2026-08-05

Abstract excerpt

<h4>ABSTRACT</h4> Riboflavin biosynthesis is required for in vitro survival of the human pathogen Mycobacterium tuberculosis ( Mtb ). However, despite the lack of a known transporter, growth can be rescued by exogenous riboflavin. The riboflavin biosynthesis pathway is also predicted essential in vivo , but whether riboflavin levels available in the host can support survival has not been directly tested. Here...

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Literature Corpus work
9353125c-9fef-5826-bf4c-ad30b0dbd722
DOI
10.64898/2026.08.04.742562
Open publication

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Loss of riboflavin biosynthesis leads to accumulation of select aromatic amino acids and loss of infectivity in <i>Mycobacterium tuberculosis</i>DOI 10.64898/2026.08.04.742562
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