Structure-aware <i>M. tuberculosis</i> functional annotation uncloaks resistance, metabolic, and virulence genes

Abstract excerpt

<h4>ABSTRACT</h4> Accurate and timely functional genome annotation is essential for translating basic pathogen research into clinically impactful advances. Here, through literature curation and structure-function inference, we systematically update the functional genome annotation of Mycobacterium tuberculosis virulent type strain H37Rv. First, we systematically curated annotations for 589 genes from 662 publica...

Topics

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• Biochemical and Molecular Research
• Bioinformatics and Genomic Networks
• Computational Drug Discovery Methods
• Mycobacterium research and diagnosis
• RNA and protein synthesis mechanisms
• Tuberculosis Research and Epidemiology

Identifiers and source

Literature Corpus work

17b8c1a9-47d2-5128-8e6f-cc1167d32b37

DOI

10.1101/358986