Back to search

Article

Orthogonal perturbation of sulfur availability reveals antibiotic-induced synthetic lethality in <i>Mycobacterium tuberculosis</i>

2026-07-28

Abstract excerpt

Despite its essential role in growth, the impact of sulfur limitation on mycobacterial physiology and antibiotic responsiveness remains poorly understood. Here, we combined chemical-genetic perturbations and infection models to investigate the consequences of sulfur limitation in Mycobacterium tuberculosis (M. tuberculosis) . We report that sulfur limitation restricted bacterial growth by rewiring metabolism, res...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0ec19df2-5c2c-5bd9-86ec-f14fb9ee8318
DOI
10.64898/2026.07.28.741166
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Orthogonal perturbation of sulfur availability reveals antibiotic-induced synthetic lethality in <i>Mycobacterium tuberculosis</i>DOI 10.64898/2026.07.28.741166
KatG inactivation generates vulnerabilities in isoniazid resistant strains of <i>Mycobacterium tuberculosis</i>Semantic proximity
Essential roles of methionine and <i>S</i> -adenosylmethionine in the autarkic lifestyle of <i>Mycobacterium tuberculosis</i>Semantic proximity
Genome scale CRISPRi reveals both shared and strain-specific vulnerabilities in genetically diverse drug-resistant strains of Mycobacterium tuberculosis.Semantic proximity
A chemical-genetic map of the pathways controlling drug potency in <i>Mycobacterium tuberculosis</i>Semantic proximity
Impaired succinate oxidation prevents growth and influences drug susceptibility in <i>Mycobacterium tuberculosis</i>Semantic proximity
<i>Mycobacterium tuberculosis</i> requires conditionally essential metabolic pathways for infectionSemantic proximity
Cysteine desulfurase (IscS)–mediated fine-tuning of bioenergetics and SUF expression prevents Mycobacterium tuberculosis hypervirulenceSemantic proximity
Elucidation of the essentiality of lumazine synthase (RibH) for <i>Mycobacterium tuberculosis</i> survival and discovery of potent inhibitors for enhanced antimycobacterial therapySemantic proximity
<i>Mycobacterium tuberculosis</i> requires the outer membrane lipid phthiocerol dimycocerosate for starvation-induced antibiotic toleranceSemantic proximity
Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis.Semantic proximity
Identifying a novel mechanism of L-leucine uptake in <i>Mycobacterium tuberculosis</i> using a chemical genomic approachSemantic proximity
Temporal genome-wide fitness analysis of <i>Mycobacterium marinum</i> during infection reveals genetic requirement for virulence and survival in amoebae and microglial cellsSemantic proximity
Select a neighboring publication to make it the new centre.