Article

Elucidation of essentiality of lumazine synthase (RibH) for Mycobacterium tuberculosis survival and discovery of potent inhibitors for enhanced antimycobacterial therapy

2023-08-07

Abstract excerpt

Tuberculosis (TB) remains a pressing global health crisis, necessitating urgent interventions to combat drug resistance and improve treatment efficacy. In this study, we elucidate the essential role of lumazine synthase (RibH) for the survival of Mycobacterium tuberculosis (M. tb). Through CRISPRi-based gene knockdown in M. tb, we confirm that deficiency of RibH – the penultimate enzyme in riboflavin biosynthesis...

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Literature Corpus work: 285ef900-f857-5e1e-8bf9-d2e2c5009b35
DOI: 10.21203/rs.3.rs-3212379/v1

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