Article

Impaired succinate oxidation prevents growth and influences drug susceptibility in <i>Mycobacterium tuberculosis</i>

2021-06-22

Abstract excerpt

Succinate is a major focal point in mycobacterial metabolism and respiration, serving as both an intermediate of the TCA cycle and a direct electron donor for the respiratory chain. Mycobacterium tuberculosis encodes multiple enzymes predicted to be capable of catalyzing the oxidation of succinate to fumarate, including two different succinate dehydrogenases (Sdh1 and Sdh2) and a separate fumarate reductase (Frd)...

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Identifiers and source

Literature Corpus work: 4414158f-750c-56c9-af08-d9ef91284d32
DOI: 10.1101/2021.06.21.449354

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