Article

Frame-specific depletion of the TRBV23-1 pseudogene in human TCR repertoires: Quantitative evidence and possible biological explanations

2025-10-02

Abstract excerpt

V(D)J recombination generates T cell receptor diversity, but most rearrangements introduce frameshifts or premature termination codons that prevent formation of functional receptors. A quantitative model was developed to estimate the expected ratio of in-frame to out-of-frame arrangements. A statistical model was used to identify repertoires with anomalous frame usage. Applied to more than 6,000 repertoires from n...

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Literature Corpus work: 65f47206-f7f4-5d96-87f9-6937361b3088
DOI: 10.1101/2025.09.30.679533

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Frame-specific depletion of the TRBV23-1 pseudogene in human TCR repertoires: Quantitative evidence and possible biological explanationsDOI 10.1101/2025.09.30.679533Read

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