Article
Frame-disrupting mutations elicit pre-mRNA accumulation independently of frame disruption.
Nucleic acids research - 1 Mar 2010
Imam J Saadi, Gudikote Jayanthi P, Chan Wai-Kin, Wilkinson Miles F
Abstract excerpt
The T-cell receptor (TCR) and immunoglobulin (Ig) genes are unique among vertebrate genes in that they undergo programmed rearrangement, a process that allows them to generate an enormous array of receptors with different antigen specificities. While crucial for immune function, this rearrangement mechanism is highly error prone, often generating frameshift or nonsense mutations that render the rearranged TCR and...
Topics
- Alternative Splicing
- Animals
- Base Sequence
- Codon, Nonsense
- Genes, T-Cell Receptor beta
- HeLa Cells
- Humans
- Mice
- Mutation
- NIH 3T3 Cells
- Protein Biosynthesis
- RNA Precursors
- RNA Stability
- RNA, Messenger
- Receptors, Antigen, T-Cell, alpha-beta
- Up-Regulation
- VDJ Exons