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Article

T cell receptor beta germline variability is revealed by inference from repertoire data.

Genome medicine - 7 Jan 2022

Omer Aviv, Peres Ayelet, Rodriguez Oscar L, Watson Corey T, Lees William, Polak Pazit, Collins Andrew M, Yaari Gur

Abstract excerpt

BACKGROUND: T and B cell receptor (TCR, BCR) repertoires constitute the foundation of adaptive immunity. Adaptive immune receptor repertoire sequencing (AIRR-seq) is a common approach to study immune system dynamics. Understanding the genetic factors influencing the composition and dynamics of these repertoires is of major scientific and clinical importance. The chromosomal loci encoding for the variable regions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34991709
DOI: 10.1186/s13073-021-01008-4
PMCID: PMC8740489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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