Article

Statistical modelling of CDR3 sequences provides robust quality control for TCR repertoire datasets

2025-12-13

Abstract excerpt

T-Cell Receptors (TCRs) show extensive sequence diversity across T cells. This diversity arises from different choices of V and J genes and from insertions and deletions at the V(D)J junction within the Complementary-Determining Region 3 (CDR3) loop. Here, we quantify how V and J gene usage shapes CDR3 length and amino acid composition. In repertoires of TCRs with either unknown or known specificity, we show that...

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Literature Corpus work: 418e302e-72bd-5e0a-a6ff-01984fb97503
DOI: 10.64898/2025.12.11.693618

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