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The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes

18 Mar 2020

Abstract excerpt

The clone size distribution of the human naive T-cell receptor (TCR) repertoire is an important determinant of adaptive immunity. We estimated the abundance of TCR sequences in samples of naive T cells from blood using an accurate quantitative sequencing protocol. We observe most TCR sequences only once, consistent with the enormous diversity of the repertoire. However, a substantial number of sequences were...

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PMID: 32187010
DOI: 10.7554/elife.49900

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