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Article

Annotation of pseudogenic gene segments by massively parallel sequencing of rearranged lymphocyte receptor loci.

Genome medicine - 23 Nov 2015

Dean Jared, Emerson Ryan O, Vignali Marissa, Sherwood Anna M, Rieder Mark J, Carlson Christopher S, Robins Harlan S

Abstract excerpt

BACKGROUND: The adaptive immune system generates a remarkable range of antigen-specific T-cell receptors (TCRs), allowing the recognition of a diverse set of antigens. Most of this diversity is encoded in the complementarity determining region 3 (CDR3) of the β chain of the αβ TCR, which is generated by somatic recombination of noncontiguous variable (V), diversity (D), and joining (J) gene segments. Deletion and...

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Share to Complementarity Determining Regions
Share to Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Molecular Sequence Annotation

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Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Receptors, Antigen, T-Cell, gamma-delta

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Source

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Identifiers

PMID: 26596423
DOI: 10.1186/s13073-015-0238-z
PMCID: PMC4657264

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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