Article

pI as a Potential Factor Influencing Evolutionary Residue Selection and Structural Stability Among Junctional Adhesion Molecules

2025-10-12

Abstract excerpt

<h4>Objective</h4> J unctional a dhesion m olecules (JAMs) are a family of conserved proteins involved in immune regulation and cell adhesion. In this study, we investigate the evolutionary and structural dynamics among three paralogs in Homo sapiens , which share similar tertiary structures but differ in isoelectric points (pI) (JAM-B: 9.23, JAM-A: 8.09, JAM-C: 7.53). <h4>Methods</h4> By integrating residue...

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Literature Corpus work: 36d3c07d-4a11-5e4a-b4d0-58d6457312b4
DOI: 10.1101/2025.10.12.681872

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