Article

Computational investigation of missense somatic mutations in cancer and potential links to pH-dependence and proteostasis

2024-07-19

Abstract excerpt

Metabolic changes during tumour development lead to acidification of the extracellular environment and a smaller increase of intracellular pH. Searches for somatic missense mutations that could reveal adaptation to altered pH have focussed on arginine to histidine changes, part of a general arginine depletion that originates from DNA mutational mechanisms. Analysis of mutations to histidine, potentially a simple r...

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Literature Corpus work: b599fc4b-75ae-56c0-bd3b-9d111966fb9d
DOI: 10.1101/2024.07.17.603952

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