Article

Computational investigation of mechanisms for pH modulation of human chloride channels

2022-10-05

Abstract excerpt

Many transmembrane proteins are modulated by intracellular or extracellular pH. Investigation of pH-dependence generally proceeds by mutagenesis of a wide set of amino acids, guided by properties such as amino acid conservation and structure. This study shows how web-based calculation of pKas allows rapid and effective identification of amino acids of interest with respect to pH-dependence. Commencing with the cal...

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Literature Corpus work: f2605e6d-e19d-5d9f-9b11-5749ac1397bb
DOI: 10.1101/2022.10.03.510624

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