Back to search

Article

A structural grammar of truncation across the human homodimer landscape

2026-05-09

Abstract excerpt

Alternative splicing and proteolytic truncation generate tens of thousands of protein isoforms in the human proteome, but the structural consequences for quaternary state, the level at which most signaling, enzymatic and regulatory function operates, have largely been examined one molecule at a time. Leveraging the recent expansion of the AlphaFold Database to predicted human homodimers, we systematically compared...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6ac09ccd-6ccf-5f8c-b20b-61c283a3d741
DOI
10.64898/2026.05.06.723091
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A structural grammar of truncation across the human homodimer landscapeDOI 10.64898/2026.05.06.723091
An atlas of protein homo-oligomerization across domains of lifeSemantic proximity
Disentangling the CHAOS of intrinsic disorder in human proteinsSemantic proximity
Most protein domains exist as variants with distinct functions across cells, tissues, and diseasesSemantic proximity
A Functional Map of the Human Intrinsically Disordered ProteomeSemantic proximity
The structural coverage of the human proteome before and after AlphaFoldSemantic proximity
Specification of Physiologic and Disease States by Distinct Proteins and Protein ConformationsSemantic proximity
Molecular grammars of intrinsically disordered regions that span the human proteomeSemantic proximity
Dissecting disease inheritance modes in a three-dimensional protein network challenges the "guilt-by-association" principle.Semantic proximity
Verification of alternative splicing variants based on domain integrity, truncation length and intrinsic protein disorder.Semantic proximity
The folding, dimerization and allosteric landscapes of the ALS protein SOD1: a comprehensive mutational atlasSemantic proximity
Alternative proteoforms and proteoform-dependent assemblies in humans and plantsSemantic proximity
Proteome-Scale Relationships Between Local Amino Acid Composition and Protein Fates and FunctionsSemantic proximity
Select a neighboring publication to make it the new centre.