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Article

High nephron endowment protects against salt-induced hypertension.

American journal of physiology. Renal physiology - 15 Jul 2012

Walker Kenneth A, Cai Xiaochu, Caruana Georgina, Thomas Merlin C, Bertram John F, Kett Michelle M

Abstract excerpt

While low nephron number is associated with increased risk of developing cardiovascular and renal disease, the functional consequences of a high nephron number are unknown. We tested the hypothesis that a high nephron number provides protection against hypertensive and renal insults. Mean arterial pressure (MAP) and renal function were characterized in male wild-type (WT) and transforming growth factor-β2...

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Identifiers

PMID: 22573381
DOI: 10.1152/ajprenal.00028.2012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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