Article

Prorenin from renal tubules is a major driver of diabetic kidney disease

2022-09-27

Abstract excerpt

The renin-angiotensin-system (RAS) plays a critical role in diabetic nephropathy, and inhibitors of the RAS are central components in its therapy. Renin circulates in the blood in its active form but also in the form of its enzymatically inactive precursor prorenin. In humans, the plasma prorenin concentration exceeds that of active renin several times. While the plasma concentration of active renin is unchanged o...

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Literature Corpus work: 7692f425-500a-5f05-a878-b7574a2139d3
DOI: 10.1101/2022.09.26.509473

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