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Article

Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic rats.

Journal of the American Society of Nephrology : JASN - 1 Jun 2004

Hoffmann Sigrid, Podlich Dirk, Hähnel Brunhilde, Kriz Wilhelm, Gretz Norbert

Abstract excerpt

Angiotensin II (AngII) is a critical determinant of glomerular function involving both hemodynamic and pressure-independent effects that are insufficiently understood. A novel transgenic rat (TGR) model with overexpression of the human AngII type 1 receptor (hAT1) in podocytes was developed to study the consequences of an increased AT1 signaling on the structure and function of the glomerular filter. Use of the...

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Identifiers

PMID: 15153558
DOI: 10.1097/01.asn.0000127988.42710.a7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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