Article
CIRKO: A chemical-induced reversible gene knockout system for studying gene function <i>in situ</i>
2022-09-03
Abstract excerpt
Conditional loss and restoration of function are becoming important approaches for investigating gene function. Given that reversible conditional gene knockouts in cells required complicated manipulation, conditional inactivation and reactivation of a gene in primary somatic cells with limited proliferative capacity and in animal models remain difficult to achieve. Here, we first developed a reportable and reversi...
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Identifiers and source
- Literature Corpus work
- 65d37d9e-8296-5dbb-8126-d8b69c8663c0
- DOI
- 10.1101/2022.08.31.506064