Article
Generation of reversible Rb-knockdown mice.
Mechanisms of ageing and development - 1 Nov 2005
Choi Yoon Sik, Lee Jae Eun, Cheong Cheolho, Sung Young Hoon, Yang Eun Young, Park Chan Bae, Song Jaewhan, Park Sang Chul, Lee Han-Woong
Abstract excerpt
This study describes the generation of reversible Rb-knockdown mice using Tet-off system coupled with Rb-deficient mice currently available. Mice expressing pRB conditionally in Rb-/- background were generated by crossings P(hCMV)-tTA/TRE-Rb transgenic mice with conventional Rb+/- mice. Transgenic Rb was tightly controlled with reversibility and biologically effective as exemplified by cyclin E expression in a...
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