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Article

Generation of a self-cleaved inducible Cre recombinase for efficient temporal genetic manipulation.

The EMBO journal - 17 Feb 2020

Tian Xueying, He Lingjuan, Liu Kuo, Pu Wenjuan, Zhao Huan, Li Yan, Liu Xiuxiu, Tang Muxue, Sun Ruilin, Fei Jian, Ji Yong, Qiao Zengyong, Lui Kathy O, Zhou Bin

Abstract excerpt

Site-specific recombinase-mediated genetic technology, such as inducible Cre-loxP recombination (CreER), is widely used for in vivo genetic manipulation with temporal control. The Cre-loxP technology improves our understanding on the in vivo function of specific genes in organ development, tissue regeneration, and disease progression. However, inducible CreER often remains inefficient in gene deletion. In order...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31943281
DOI: 10.15252/embj.2019102675
PMCID: PMC7024834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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