Article

A Dual-Function 'TRE-Lox" System for Genetic Deletion or Reversible, Titratable, and Near-Complete Downregulation of Cathepsin D

2023-03-31

Abstract excerpt

Commonly employed methods for reversibly disrupting gene expression, such as those based on RNAi or CRISPRi, are rarely capable of achieving >80-90% downregulation, making them unsuitable for targeting genes that require more complete disruption to elicit a phenotype.&ensp;Genetic deletion, on the other hand, while enabling complete disruption of target genes, often produces undesirable irreversible consequence...

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Literature Corpus work: 7992a37a-c7d2-598c-994b-50a6ec34365b
DOI: 10.20944/preprints202303.0543.v1

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